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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
18/02/2019 |
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Data da última atualização: |
24/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TRÍBULO, P.; BALZANO-NOGUEIRA, L.; CONESA, A.; SIQUEIRA, L. G. B.; HANSEN, P. J. |
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Afiliação: |
PAULA TRÍBULO, University of Florida, Gainesville, Florida; LEANDRO BALZANO-NOGUEIRA, University of Florida, Gainesville, Florida; ANA CONESA, University of Florida, Gainesville, Florida; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; PETER J. HANSEN, University of Florida, Gainesville, Florida. |
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Título: |
Changes in the uterine metabolome of the cow during the first 7 days after estrus. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Molecular Reproduction and Development, v. 86, n. 1, p. 75-87, 2019. |
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DOI: |
10.1002/mrd.23082 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 (N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco's phosphate-buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic development. Data reported here will serve as the basis for future studies aiming to evaluate maternal regulation of preimplantation embryonic development and optimal conditions for the culture of embryos. MenosAbstract The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 (N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco's phosphate-buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic ... Mostrar Tudo |
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Palavras-Chave: |
Histotroph; Maternal-embryo crosstalk. |
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Thesaurus Nal: |
Endometrium; Metabolome. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02392naa a2200229 a 4500
001 2106149
005 2023-01-24
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1002/mrd.23082$2DOI
100 1 $aTRÍBULO, P.
245 $aChanges in the uterine metabolome of the cow during the first 7 days after estrus.$h[electronic resource]
260 $c2019
520 $aAbstract The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 (N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco's phosphate-buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic development. Data reported here will serve as the basis for future studies aiming to evaluate maternal regulation of preimplantation embryonic development and optimal conditions for the culture of embryos.
650 $aEndometrium
650 $aMetabolome
653 $aHistotroph
653 $aMaternal-embryo crosstalk
700 1 $aBALZANO-NOGUEIRA, L.
700 1 $aCONESA, A.
700 1 $aSIQUEIRA, L. G. B.
700 1 $aHANSEN, P. J.
773 $tMolecular Reproduction and Development$gv. 86, n. 1, p. 75-87, 2019.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Hortaliças. Para informações adicionais entre em contato com cnph.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Hortaliças. |
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Data corrente: |
17/02/2012 |
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Data da última atualização: |
17/02/2012 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 2 |
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Autoria: |
MATTOS, L. M.; PINHEIRO, J. B.; MENDONCA, J. L. de; SANTANA, J. P. de. |
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Afiliação: |
LEONORA MANSUR MATTOS, CNPH; JADIR BORGES PINHEIRO, CNPH; JOSE LINDORICO DE MENDONCA, CNPH; J. P. de SANTANA. |
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Título: |
Wild Solanaceae: potential for the use as rootstocks resistant to rootknot nematode (Meloidogyne spp.) |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Acta Horticulturae, The Hague, v. 917, p. 243-247, Dec. 2011 |
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Idioma: |
Inglês |
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Notas: |
Trabalho apresentado na 28. International Horticultural Congress on Science and Horticulture for People : International Symposium on Plant Protection, Lisbon, 2010. |
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Conteúdo: |
The objective of this study was to evaluate the reaction of the wild Solanaceae, Solanum asperolanatum Ruiz and Pau, Solanum stramonifolium Jacq.k Solanum sp., Solanum paniculatum L., and S. subineme Jacq. for resistance to the root-knot nematodes M. incognita race I and M. mayaguensis. |
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Thesagro: |
Meloidogyne Incognita; Nematoide; Tomate. |
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Thesaurus NAL: |
Solanum lycopersicum. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 01079naa a2200217 a 4500
001 1916050
005 2012-02-17
008 2011 bl --- 0-- u #d
100 1 $aMATTOS, L. M.
245 $aWild Solanaceae$bpotential for the use as rootstocks resistant to rootknot nematode (Meloidogyne spp.)
260 $c2011
500 $aTrabalho apresentado na 28. International Horticultural Congress on Science and Horticulture for People : International Symposium on Plant Protection, Lisbon, 2010.
520 $aThe objective of this study was to evaluate the reaction of the wild Solanaceae, Solanum asperolanatum Ruiz and Pau, Solanum stramonifolium Jacq.k Solanum sp., Solanum paniculatum L., and S. subineme Jacq. for resistance to the root-knot nematodes M. incognita race I and M. mayaguensis.
650 $aSolanum lycopersicum
650 $aMeloidogyne Incognita
650 $aNematoide
650 $aTomate
700 1 $aPINHEIRO, J. B.
700 1 $aMENDONCA, J. L. de
700 1 $aSANTANA, J. P. de
773 $tActa Horticulturae, The Hague$gv. 917, p. 243-247, Dec. 2011
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